ddc

• دواء مضاد للفيروسات يُستخدم لعلاج عدوى فيروس العوز المناعي البشري (HIV)؛ يثبط إنزيم الناسخ العكسي فيمنع الفيروس من التكاثر.

An antiretroviral medication used in the treatment of HIV infection; a nucleoside reverse transcriptase inhibitor that hinders the ability of the virus to multiply.

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1. An antiviral drug used to combat HIV infection, often employed in combination with other medications.C2formalmedical

   A synthetic nucleoside analogue, also known as zalcitabine, that acts against the Human Immunodeficiency Virus. As a dideoxycytidine, it is phosphorylated within cells to its active triphosphate form, which competes with the natural substrate deoxycytidine triphosphate for incorporation into viral DNA, thereby terminating chain elongation and inhibiting viral replication. Its clinical use has significantly diminished due to toxicity and the availability of safer alternatives.

   دواء مضاد للفيروسات لعلاج عدوى فيروس العوز المناعي البشري

   • Zalcitabine, abbreviated as DDC, was among the early nucleoside analogues approved for HIV treatment.
   • The regimen combining DDC with a protease inhibitor showed improved survival rates in the trial.
   • Peripheral neuropathy is a common and potentially severe side effect of DDC therapy.
   • Due to its toxicity profile, DDC has been largely replaced by newer antiretroviral agents.
   • The virologist explained how DDC is incorporated into the growing DNA strand, causing premature termination.

   المرادفاتzalcitabine