ddc

• 一种抗病毒药物，用于治疗艾滋病（HIV感染）；通过抑制病毒的逆转录酶来阻止病毒复制。

An antiretroviral medication used in the treatment of HIV infection; a nucleoside reverse transcriptase inhibitor that hinders the ability of the virus to multiply.

不可数 · 专有名词

1. An antiviral drug used to combat HIV infection, often employed in combination with other medications.C2formalmedical

   A synthetic nucleoside analogue, also known as zalcitabine, that acts against the Human Immunodeficiency Virus. As a dideoxycytidine, it is phosphorylated within cells to its active triphosphate form, which competes with the natural substrate deoxycytidine triphosphate for incorporation into viral DNA, thereby terminating chain elongation and inhibiting viral replication. Its clinical use has significantly diminished due to toxicity and the availability of safer alternatives.

   抗HIV核苷类似物药物

   • Zalcitabine, abbreviated as DDC, was among the early nucleoside analogues approved for HIV treatment.
   • The regimen combining DDC with a protease inhibitor showed improved survival rates in the trial.
   • Peripheral neuropathy is a common and potentially severe side effect of DDC therapy.
   • Due to its toxicity profile, DDC has been largely replaced by newer antiretroviral agents.
   • The virologist explained how DDC is incorporated into the growing DNA strand, causing premature termination.

   同义词zalcitabine