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secretase

/sɪˈkriː.teɪz/

Übersetzung: Sekretasen sind Enzyme (Proteasen), die Transmembranproteine spalten und dabei Peptidfragmente freisetzen; sie spielen eine Schlüsselrolle bei der Entstehung der Amyloid-Beta-Plaques im Gehirn, einem Kennzeichen der Alzheimer-Krankheit.

1 Eintrag

noun

/sɪˈkriː.teɪz/C2formalmedical
  • deSekretasen sind Enzyme (Proteasen), die Transmembranproteine spalten und dabei Peptidfragmente freisetzen; sie spielen eine Schlüsselrolle bei der Entstehung der Amyloid-Beta-Plaques im Gehirn, einem Kennzeichen der Alzheimer-Krankheit.

A set of enzymes that cleave a longer protein into fragments, producing amyloid protein pieces that aggregate into plaques in brain tissue, a key pathological feature of Alzheimer's disease.

  1. Enzyme involved in Alzheimer's diseaseC2formalmedical

    A type of enzyme that cuts a larger protein into smaller fragments, including amyloid beta peptides, which can accumulate in the brain and form plaques associated with Alzheimer's disease.

    deEnzym bei Alzheimer-Krankheit

    • Researchers are studying how secretase activity contributes to plaque formation.
    • Inhibitors of secretase are being tested as potential treatments for Alzheimer's.
    • The enzyme secretase plays a key role in the production of amyloid beta.